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Mixed cellularity and lymphocyte depleted form of classical HL are the predominant pathologic subtypes and bone marrow involvement is found in about half of patients.
Bone and bone marrow involvement is unusual.
Focal bone marrow involvement is typical in HL.
Bone marrow involvement is usually not identified unless a lytic bone lesion is present.
Bone marrow involvement is assessed by both imaging and bone marrow aspirate and biopsy.
Bone marrow involvement is extremely rare (Cazals-Hatem et al, 1996; Abou-Ella et al, 1999).
Similar(47)
The CNS, with or without concomitant bone marrow involvement, was the first site of relapse in 19 (13%) of the 142 SR patients: 16 (20%) of 79 SR boys and three (5%) of 63 SR girls.
While most cases of ALCL with peripheral blood and bone marrow involvement were ALK-positive or carrying t(2 5) translocation, rare ALK-negative cases were also present.
Bone marrow involvement was defined by bone marrow aspiration and/or biopsy with a dense focal or diffuse mast cell infiltrate with spindle-shaped cells [15].
In agreement with those findings, previous reports have also shown that bone marrow involvement was significantly more frequent in adult (45% 90% [17] [18] than in pediatric (18%) [19] patients.
Bone marrow involvement was positive in 11 % of patients.
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