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Montanari F, O'Connor OA, Savage DG, Zain JM, Venkatraman S, McCormick EK, Crook MT, Tsao L, Sevilla DW, Bhagat G, Alobeid B. Bone marrow involvement in patients with posttransplant lymphoproliferative disorders: incidence and prognostic factors.
CONCLUSIONS:Hepatosplenomegaly and pallor resulting from nutritional deficiency or bone marrow involvement in Wolman disease can mimic infant leukemia.
Visceral involvement was present in 103 cases (77 %) with bone marrow involvement in 51 cases (49%% of them).
Some clinical factors correlated with bone marrow involvement in either data set (Table 2).
The distribution of neoplastic bone marrow involvement in patients with hematologic malignancies may be focal, multifocal or diffuse.
Bone marrow involvement in follicular lymphoma is the result of an invasion by malignant B cells into the tissue.
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They are usually characterized by a diffuse disease process in 68 %, systemic symptoms in nearly half (45 %), bone marrow involvement (BMI) in a quarter (26 %), and extra nodal diseases in a third (37 %) of the patients [ 3].
Metaiodobenzylguanidine (mIBG) scintigraphy is valuable in assessing bone and bone marrow involvement and in following response to therapy.
In the first set, the bone marrow CD4/CD8 ratios were significantly higher in patients who had bone marrow involvement than in those who did not (P=0.043; Table 1).
This study was designed to identify variables that can predict bone marrow involvement (BMI) in Hodgkin's lymphoma (HL), and to analyze the benefit of bilateral over unilateral bone marrow trephine biopsy (BMB).
Bone marrow involvement, seen in 40 70% of cases, is also an important adverse factor for outcome, even in the current era of therapy with the anti-CD20 monoclonal antibody rituximab.
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