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The bone marrow infiltration has to be high enough to result in a decrease in fat cells, detectable on conventional and diffusion weighted MRI (Fig 10) [10].
Bone marrow infiltration has to be high enough to result in a decrease in fat cells, detectable on conventional and diffusion-weighted MRI [16] (Figs. 6b and 7b).
Similar(58)
PET is useful for detecting lytic bone deposits and marrow infiltration but has limitations in the detection of osteoblastic deposits.
Evidence of infiltration has been steadily growing.
The levels of infiltration have gone down.
MRI remains the most sensitive and specific imaging method for the detection of bone marrow infiltration, before mineralized bone has been destroyed [8].
Strict INSS staging does not include stage 4s NB infants with tumoral bone marrow infiltration exceeding 10%, which has been reported as extremely rare (one patient in 80, Nickerson et al, 2000).
Five different patterns of bone marrow infiltration in multiple myeloma have been identified on MR imaging, including a normal appearing marrow, focal infiltration, diffuse disease, salt-and-pepper involvement or combined focal and diffuse infiltration (Fig 9) [35] 35].
Myelotoxicity is more severe in patients who have bone marrow infiltration by tumour at the time of treatment or who have undergone previous chemotherapy or radionuclide therapy.
The conclusion was phrased in the following manner: For the detection of bone marrow infiltration, at mean threshold PET has a sensitivity of 64%9595% CI: 43% to 80%), and a specificity of 88%9595% CI: 76% to 95%).
Twenty-four per cent (six out of 25) required transfusion of red cells within 6 months of the therapy however it is unclear whether this is related to the treatment as many of these patients had extensive bone marrow infiltration.
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