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Studies on the effects of rituximab treatment on different compartments (like peripheral blood, synovial tissue, and bone marrow) in relation to the clinical response may provide insight into the mechanism of action in RA.
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However, the effects of G-CSF on bone marrow cells in relation to vascular injury have not been fully clarified, especially during the development of neointimal hyperplasia.
The effects of granulocyte-colony stimulating factor (G-CSF) on bone marrow cells in relation to vascular lesions have not yet been fully clarified, especially during the process of neointimal hyperplasia.
With quantitative RT-PCR techniques that enable an estimate of the number of reference gene transcripts in bone marrow cells in relation to the marker gene transcripts (eg cytokeratin), a cutoff level can be created to distinguish between malignant and nonmalig-nant cells [ 25].
The contribution of the cross-dose to the red marrow dose was substantial in relation to the contribution of the self-dose (Table 1).
This study showed the presence of important changes occurring in the bone marrow niche before disease onset in relation to mesenchymal progenitors, adipogenesis and osteoclastogenesis.
Although the importance of micrometastatic bone marrow involvement of most solid tumors in relation to poor prognosis has long been recognized, the nature of these bone marrow metastatic tumor cells has not been well defined [ 15, 17, 18].
Twenty days p. i., corresponding native bone marrow cells from arthritic rats showed a significantly higher percentage of cells positive for macrophage markers CD11b and EMR1 in relation to bone marrow from healthy controls (Fig. 1b).
MRI showed bone marrow oedema-like change and synovitis in relation to the sternoclavicular joints and less marked in relation to the corpomanubrial joint of the sternum (a, coronal STIR).
A similar trend was noticed in the bone marrow, although the difference was not significant in relation to IgG1.
The aim of this article is to review radiological findings involving the intervertebral discs, end plates, bone marrow changes, facet joints and the spinal canal in relation to the pathogenesis of degenerative changes in the spine.
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