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Whether the new endothelial cells required for this expansion are derived from the existing local vasculature, or if they are recruited from the bone marrow, has not been previously studied.
The fate of neutrophils that home to the bone marrow has not been previously defined.
According to the newest guidelines related to the diagnosis of bone marrow and lymphatic system malignancies issued by the World Health Organization (WHO), the importance of microscopic examinations of bone marrow has not decreased; rather, more precise morphological criteria were defined, where needed, to avoid ambiguity.
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Athersys's cells, derived from human bone marrow, have not yet been tested in people with inflammatory bowel disease, a term that encompasses ulcerative colitis and Crohn's disease.
To test their artificial marrow further, they added influenza viruses, and found that it released antibodies to fight the viruses, just as natural marrow would.The anticancer and antiviral drugs that damage natural marrow have not been studied in the artificial version yet, but that should happen soon.
They found that it released antibodies to fight those viruses in exactly the way that natural marrow would.The anti-cancer and anti-viral drugs that damage natural marrow have not been studied in the artificial version yet, but that should happen soon.
In secondary lymphoid organs, Th cells can interact with malignant cells of mature B cell origin, while such interactions between Th cells and malignant immature B cell in the bone marrow have not been described yet.
In the literature, the stromal cell types in bone marrow have not been characterized as extensively as those in thymus.
While an increase in bone marrow adiposity is associated with age-related bone disease, the function of bone marrow adipocytes has not been studied.
The bone marrow has been identified as a site of latent infection [37] but the nature of the infected bone marrow cell has not been determined.
Though the cells that contributed to the patients' skin, gut and liver presumably came from the donors' bone marrow, this has not been proved.
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CEO of Professional Science Editing for Scientists @ prosciediting.com