Sentence examples for marrow has led from inspiring English sources
The associated morbidity from the acquisition of mesenchymal stem cells (MSC) from the bone marrow has led to the investigation of alternative stem cell sources.
In primary breast cancer, the detection of microscopic disease in lymph nodes and bone marrow has led to a better understanding of the role of minimal residual disease (MRD).
This suggests that each gray of radiation to the red bone marrow has led to 0.012 excess leukaemias or myelodysplasias to date, and that the excess rate ratio for leukaemias and myelodysplasias per mGy to the red bone marrow is 0.039 955% confidence interval 0.014 to 0.070).
However, the low frequency of progenitor cell populations in bone marrow aspirates has led to various approaches to obtain large numbers of MSCs.
A better understanding of the mechanisms by which cytokines support the functions of resident cells and circulating bone marrow-derived cell populations has led to the development of a number of therapeutic angiogenesis strategies.
In patients with telomere syndromes who require bone marrow transplantation, the experience of recent decades has led to a significant alteration in the approach to bone marrow transplant with improved short-term outcomes [ 19], [ 20].
This research has led to the first clinical application of autologous bone marrow stromal cells for the repair of full-thickness articular cartilage defects in humans [ 5, 6].
In previous reports on intrauterine transplantation with T-cell-depleted bone marrow, repeated injections have led to partial immunoreconstitution at birth, with subnormal T-cell counts and a delayed response to mitogens.
Over the past 20 years, more aggressive chemotherapeutic regimens, availability of bone marrow transplantation (BMT), and development of subtype-directed therapies have led to improved survival[ 2].
This could have led to a higher risk for material extravasation as well as bone marrow and fat particles being forced out into the systemic circulation.
