Sentence examples for marrow graft from inspiring English sources
There is a tendency for the patient to reject the allografted marrow, and there is an additional hazard because immune-system cells in a marrow graft can react against the patient's tissues, causing serious and sometimes fatal graft-versus-host disease.
It is a particular gamble if the child is conceived partly to provide a bone marrow graft for a brother or sister with a nasty genetic disease: not only might the new baby turn out be a poor match for transplantation, but might also have inherited the same disorder as his or her sibling.A test-tube trick, pre-implantation genetic diagnosis (PGD), helps reduce this risk.
These strategies include the use of non-ablative conditioning regimens, the use of peripheral blood stem cells rather than bone marrow, graft engineering and targeted conditioning therapies such as bone-seeking radioisotopes.
Mature T cells infused with the bone marrow graft respond to alloantigens and other changes in the allogeneic host tissues induced by the pre-transplantaion conditioning.
All donors were healthy donors in a bone marrow graft program and informed consent was given.
Patients predominantly received a bone marrow graft (72%) and total body irradiation based conditioning regimen (75%).
In other studies, the incidence of IA was evaluated as a frequency of 1 to 28% for patients with allogenous bone marrow transplant graft [ 14, 19].
Thomas adopted methods to match the tissues of donor and recipient closely enough to minimize the latter's rejection of the former's marrow (graft-versus-host disease), and he also developed techniques to reduce the chances of transplant rejection.
Marrow grafting is then necessary to rescue the patient.
Diseases in which the bone marrow is defective, such as aplastic anemia, may be treated by marrow grafting.
Dr. Kaufman said he was now working on the problem and would need to show that the cells could make long-surviving bone marrow grafts to prove they included hematopoietic stem cells.
