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Long-term exposure may be followed by bone marrow depression, anemia, spontaneous bleeding, and leukemia.
The limited toxicity of the treatment was mainly related to reversible bone marrow depression.
They include nausea, vomiting, bone marrow depression, alopecia, and renal dysfunction [125, 126].
Furthermore, the long-term use of indomethacin in the elderly has been reported to be associated with a greater risk of fatal adverse events, such as bleeding or perforation of a gastric ulcer, and bone marrow depression or leukemia [28], while celecoxib shows good tolerability and safety [8].
Cisplatin was given during the whole course of radiotherapy to only one quarter of the patients in the CF arm, stopping mostly after 5 6 weeks due to bone marrow depression and kidney toxicity, while patients in the MFD arm received it according to schedule.
Local delivery of antiepileptic drugs to brain tissue might improve the therapeutic/toxic ratio, since side effects such as hepatotoxicity, bone marrow depression, rash, and many other undesirable consequences are not intrinsic to the necessary actions of the drug on seizures.
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Given a resemblance of the chemical structure and similar pharmacological profile, it has been speculated that quetiapine could cause bone-marrow depression similar to clozapine [ 2].
Bone-marrow depression is the most common side-effect in association with hypomethylating agents, while classical cytotoxic side-effects, such as hair loss, mucositis, diarrhoea, and renal failure are rare (Issa and Kantarjian 2009).
The survival rate was improved by 5% with adjuvant chemotherapy after resection, so regimen consist of platinum-based two chemical medicines are commended as the adjuvant chemotherapy for treating postoperative NSCLC patients, but the toxicity and side effects of chemotherapy such as nausea and vomiting, hair loss, and bone-marrow depression can decrease quality of life (QOL) of patients [ 4- 6].
But earlier this year he fell silent owing to a minor stroke - another notch on his life's long list of maladies including childhood bone marrow cancer, depression and peritonitis.
According to the article, "hippy crack" is capable of causing "strokes, hallucinations, seizures, blackouts, incontinence, stress on the heart, chronic depression and even in cases of prolonged use depleted bone marrow".
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