Sentence examples for marrow chimeras reconstituted from inspiring English sources

(E and F ) The frequency of MCC-tetramer+ peripheral CD4+ T cells in B6.K or gp250 SC bone marrow chimeras reconstituted with B6.K bone marrows.

Even in bone marrow chimeras reconstituted with a mixture of CD45.2+ RAnaef1 andef and CD45.1+ wildtype marrow, the Rasgrp1 Anaef thymocytes exhibited no competitive disadvantage as they matured from DP to SP cells.

Conversely, at day 19, chimeras lacking hematopoietic CD34 expression exhibited reduced intra-tumoral mast cell numbers, compared to chimeras reconstituted with wildtype bone marrow (Figure 6F).

We generated bone marrow chimeras by reconstituting lethally irradiated Lmna+/+ mice with Lmna+/+ or Lmna-/ bone marrow to determine whether the defects in T and B cell development and homeostasis were cell-autonomous.

To assess the immunocompetence of Lmna-/ CD4+ and CD8+ T cells that appear to develop normally in Lmna+/+ bone marrow chimeric hosts, we generated Lmna+/+/Lmna-/- Lmna+/+/Lmna-/-ow chimixed boneeconstituting lethally-irradiated Lmarrow michimerasa mix of Lmna+/+ and Lmna-/- byne mareconstituting

(B ) Ratio of blt /+ (CD45.2+) vs WT (CD45.1+CD45.2+) cells in splenic NK cells and indicated thymocyte and T cell populations from irradiation chimeras reconstituted with a mix of blt /+ and WT bone marrow as in Figure 1F.

Flow cytometry plots shown are for chimeras reconstituted with Ankle2- or empty vector-transduced Rag1-GFP boneblt bone marrow.

(F ) The Vα11 and Vβ3 expression of thymic CD4SP or peripheral CD4+ T cells in B6.K or gp250 SC bone marrow chimeras reconstituted with B6.K HSC cells.

To explore this possibility, we constructed bone marrow chimeras in which lethally irradiated C57BL/6 mice were reconstituted with allogeneic BALB/c bone marrow.

Bone marrow chimeras were generated using the Ly5.1/5.2 reconstitution system, as previously described [6].

Furthermore, the generation of SJL FCG bone marrow chimeras identified an effect of XY on CNS neurodegeneration, where having an XY CNS confers greater spinal cord and cerebellar pathology in SJL chimeric mice reconstituted with the same immune system, but differing in the sex Chr complement in the CNS [ 64].