Although no changes in bone marrow cellularity were observed in mice treated with HQ, cellularity was decreased by a factor of two in the mice that had received HQ plus PHE.
Mean cellularity observed was 13.3 % for both groups.
A trend toward an overall downregulation of apoptosis-associated genes could be observed in megakaryocytes, whereas the total bone marrow cellularity exhibited an overall upregulation of these factors.
The decrease of marrow cellularity leads to an increase of fatty content: an increased signal intensity is observed on T1W images and a hypo-intense signal intensity on fat-suppression sequences.
The decrease in marrow cellularity leads to an increase in fatty content: an increase signal intensity is observed on T1-weighted images and a hypointense signal intensity on fat-suppression sequences.
The score was intended to be relatively straightforward, and similar to the estimation of bone marrow cellularity on core biopsies, which has high inter-observer reproducibility5 and is a familiar task to many pathologists.
Olnes et al. [ 7] observed clinically significant responses in erythroid, neutrophil, and platelet lineages, with normalization of bone marrow cellularity and trilineage hematopoiesis after eltrombopag treatment.
Aging decreases bone marrow cellularity and alters the frequencies of stem cells.
This is not surprising since we modeled our score after the assessment of bone marrow cellularity, which is a practice that is widely-accepted clinically and highly reproducible between pathologists5.
In the group of myeloproliferative neoplasm, unclassifiable patients with a primary myelofibrosis-like morphology, the overall bone marrow cellularity resulted increased in most of the cases (85%), without a significant hyperplasia of the granulopoietic series.
