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Most of the differentially expressed genes in the present study are involved in bone marrow cell differentiation, cell growth or growth arrest, apoptosis, cell adhesion and matrix modulation, and inflammatory and immune response, processes known to modulate atherosclerosis.
Combining molecular and biochemical analyses, it was found that bone marrow cell differentiation was stimulated over proliferation on GC-ICEL.
BMnCs may improve lung injury due to bone marrow cell differentiation into epithelial and endothelial cells [ 81].
Recent advances in the elucidation of the pathophysiology of osteoporosis in the elderly indicate that the loss of balance between osteoblastogenesis and adipogenesis in bone marrow cell differentiation is a key mechanism of osteoporosis in older adults [ 21].
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Pathological stimulations like malignant tumor and inflammation block immature bone marrow cells differentiation into mature cells, leading to the expansion of MDSCs and contributing to the negative regulation of tumor immune response.
Schiff, C., Lemmers, B., Deville, A., Fougereau, M. & Meffre, E. Autosomal primary immunodeficiencies affecting human bone marrow B cell differentiation.
Substrates with mechanical property gradients and various extracellular matrix ligand loadings were evaluated for their ability to direct bone marrow stromal cell differentiation along osteogenic and tenogenic lineages.
We have previously shown that this particular group of BMPs is all co-expressed and regulated as a network during marrow stromal cell differentiation, and this network is under the control of BMP2 [16].
While our observations do not demonstrate functionality of these genes in a post natal context, the examination of one of these genes Nanog was shown to be induced in different forms of injury induced skeletal repair and during marrow stromal cell differentiation in vitro.
The resultant production of inflammatory cytokines and endogenous glucocorticoids initially stimulate the osteoblasts to produce RANK ligand, which stimulates marrow stem cell differentiation into osteoclasts.
The thymus is the primary lymphoid organ in which T cell precursors derived from the bone marrow undergo cell differentiation process consisting of the sequential expression of multiple lymphocyte differentiation genes and rearrangement of the T cell receptor (TCR) genes.
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