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The IPSS was revised (IPSS-R) to incorporate expanded cytogenetic categories, greater discrimination in bone marrow blast thresholds, and severity of cytopenias [ 6].
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Furthermore, FLT3 expression showed a weak but significant correlation with bone marrow blast counts (r = 0.36, p = 0.049).
*Bone marrow blast percentage.
Twentypercentt achieved a reduction in marrow blast count, with less than 5% blasts at morphologic exam.
Factors negatively influencing response were AML (vs. MDS), marrow blast count, pretreatment, and transfusion dependency.
No change in bone marrow blast count was observed in two patients on day 15.
In 70% of AML patients, there was a 50% reduction of peripheral blood blast cells, and in 25% of patients a 50% reduction in bone marrow blast cells.
Bone marrow blast clearance at the end of chemotherapy was evaluated at day 10 in 14 patients.
He started with a marrow blast count of 15% in March 2007, which was virtually unchanged (18%) prior to cycle 5.
[Table 2] No correlation was observed between pretherapeutic nucleosomal DNA levels and bone marrow blast number (r = 0.08; p = 0.722).
Further GO therapy controlled the bone marrow blast count, with no significant adverse effects, for 12.5 months after SCT.
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