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Furthermore, FLT3 expression showed a weak but significant correlation with bone marrow blast counts (r = 0.36, p = 0.049).
In the IPSS, three different cytogenetic subgroups were established and weighted against bone marrow blast counts and cytopenias by multivariate analysis [ 2].
For patients with acute myeloid leukemia and low bone marrow blast counts, azacitidine appears to be an effective treatment, with superior median survival and lower 30-day mortality than standard induction therapy in older patients.
Two patients (#4 and #6) who received three GO doses of 3 mg/m2 (on days 1, 4 and 7) had no change in their bone marrow blast counts on day 15.
Patient characteristics appearing to negatively influence OS at the 0.05 level included advanced age, poorer baseline ECOG PS, poor cytogenetic risk, higher bone marrow blast counts, low baseline platelet counts, and higher WBC counts.
Median survival not reached A further element of the IPSS, the weighting of cytogenetics in comparison to other relevant parameters like the bone marrow blast counts, has become questionable.
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Twentypercentt achieved a reduction in marrow blast count, with less than 5% blasts at morphologic exam.
Factors negatively influencing response were AML (vs. MDS), marrow blast count, pretreatment, and transfusion dependency.
No change in bone marrow blast count was observed in two patients on day 15.
He started with a marrow blast count of 15% in March 2007, which was virtually unchanged (18%) prior to cycle 5.
Further GO therapy controlled the bone marrow blast count, with no significant adverse effects, for 12.5 months after SCT.
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