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Fenaux, P. et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia.
11 patients that were classified as lower-risk (LR) MDS patients had a lower marrow blast count (<5%, range 0 3%) while 10 were classified as higher-risk (HR) MDS patients and had a higher marrow blast count (>5%, 6 13%).
Factors negatively influencing response were AML (vs. MDS), marrow blast count, pretreatment, and transfusion dependency.
No change in bone marrow blast count was observed in two patients on day 15.
Further GO therapy controlled the bone marrow blast count, with no significant adverse effects, for 12.5 months after SCT.
Twentypercentt achieved a reduction in marrow blast count, with less than 5% blasts at morphologic exam.
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Corticosteroid drug response was measured by reduction in bone marrow blast counts and absolute peripheral blast counts after 3 days.
Furthermore, FLT3 expression showed a weak but significant correlation with bone marrow blast counts (r = 0.36, p = 0.049).
In the IPSS, three different cytogenetic subgroups were established and weighted against bone marrow blast counts and cytopenias by multivariate analysis [ 2].
Patient characteristics appearing to negatively influence OS at the 0.05 level included advanced age, poorer baseline ECOG PS, poor cytogenetic risk, higher bone marrow blast counts, low baseline platelet counts, and higher WBC counts.
Additionally, poorer baseline ECOG PS and disease-related factors, such as poor cytogenetics, higher bone marrow blast counts, low baseline platelet counts, and high WBC counts, all predicted worse OS.
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