ELN response was achieved in 21.0% of the 371 patients (CI95% 17.0 25.5) and did not depend on bone marrow blast cell percentage.
Furthermore, FLT3 expression showed a weak but significant correlation with bone marrow blast counts (r = 0.36, p = 0.049).
*Bone marrow blast percentage.
Twentypercentt achieved a reduction in marrow blast count, with less than 5% blasts at morphologic exam.
Factors negatively influencing response were AML (vs. MDS), marrow blast count, pretreatment, and transfusion dependency.
No change in bone marrow blast count was observed in two patients on day 15.
Eleven of the 12 patients with circulating leukaemic cells had blood blast clearance, two achieved complete remission and one with blast crisis of CMML returned in chronic phase.
In 70% of AML patients, there was a 50% reduction of peripheral blood blast cells, and in 25% of patients a 50% reduction in bone marrow blast cells.
He started with a marrow blast count of 15% in March 2007, which was virtually unchanged (18%) prior to cycle 5.
[Table 2] No correlation was observed between pretherapeutic nucleosomal DNA levels and bone marrow blast number (r = 0.08; p = 0.722).
