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Corticosteroid drug response was measured by reduction in bone marrow blast counts and absolute peripheral blast counts after 3 days.
The recently developed Revised International Prognostic Scoring System provides improved prognostication using more refined cytogenetic, marrow blast, and cytopenia parameters.
Fenaux, P. et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia.
11 patients that were classified as lower-risk (LR) MDS patients had a lower marrow blast count (<5%, range 0 3%) while 10 were classified as higher-risk (HR) MDS patients and had a higher marrow blast count (>5%, 6 13%).
ELN response was achieved in 21.0% of the 371 patients (CI95% 17.0 25.5) and did not depend on bone marrow blast cell percentage.
Glucocorticoid receptor (GCR) number and the effective concentration of dexamethasone resulting in a 50% reduction of leukemic cell viability in vitro (EC-50) were evaluated at days 0 and 3.Increasing dexamethasone doses resulted in greater marrow blast response (P =.007), with a similar trend in peripheral-blood blast response.
Patients: Consecutive series of 59 patients with myelodysplasia or closely related disorders and either life-threatening cytopenia or a progressive increase in marrow blast percentage.
The International Prognostic Scoring System (IPSS) identified three critical factors that influence survival and AML evolution: risk-based cytogenetic subgroups (good, intermediate and poor karyotypes), bone marrow blast percentage and the number of cytopenias.
Furthermore, FLT3 expression showed a weak but significant correlation with bone marrow blast counts (r = 0.36, p = 0.049).
*Bone marrow blast percentage.
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For each patient, the bone marrow blast-cell level was > 80%.
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