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A subset of myeloproliferative disorders (MPN) and myelodyplastic syndromes (MDS) evolves to fibrosis of the bone marrow associated with haematopoietic insufficiency.
Neoplastic cells are found in the bone marrow associated with displacement of normal haematopoietic cells and, in most cases, also in peripheral blood.
DOI: http://dx.doi.org/10.7554/eLife.03696.003 10.7554/eLiFigure96.004 Figure 1 figure supplement 1. Perivascular and endothelial Nes-GFP+ cells invade the incipient bone marrow associated with blood vessels.
Corroborative evidence of our interpretation was the presence of benign lymphocytic aggregates in the bone marrow associated with particle-laden macrophages as previously reported in hip resurfacing implants [ 15, 40].
In contrast, expression of the MSC marker CD90, enriched in Nes-GFP+ cells, was reduced two-fold in Erbb3−/− limb bone marrow, associated with 5-fold drop in the number of bone marrow hematopoietic progenitors.
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Histopathological findings revealed hypoxic tissue necrosis in liver, marrow, spleen and heart, associated with pleural and peritoneal fluid and edema [16], [24].
GFP+ cells were already present in E16.5 bone marrow, associated preferentially with blood vessels infiltrating the cartilage scaffold.
The team announced his death, saying he had a bone marrow malignancy associated with lung and liver disease.
Schutt, R. C. et al. Bone marrow characteristics associated with changes in infarct size after STEMI: a biorepository evaluation from the CCTRN TIME trial.
Initial attempts at haploidentical transplantation using unmanipulated bone marrow were associated with a high transplant-related mortality.
These changes were entirely dependent on changes in the microenvironment, with a marked increase in trabecular bone and marrow vascularity associated with increased VEGF, but without cell-autonomous alterations in stem cell characteristics.
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