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Bone marrow aspirate concentrate.
Overall, bone marrow aspirate appears to be a safe biologic adjunct.
Bone marrow aspirate consists of both mesenchymal stem cells (MSCs) and hematopoietic stem cells.
We have established a clonal adult human cell line (C1) derived from a bone marrow aspirate.
However, the bone marrow aspirate is an invasive and painful procedure for the donor.
Bone marrow aspirate (BMA) provides an autologous source of osteoprogenitors for such applications.
Bone marrow aspirate (BMA) has shown promise as a bone graft option in spinal fusion.
Autologous concentrated bone marrow aspirate (cBMA) and platelet-rich plasma (PRP) increase osteogenic potential of demineralized bone matrix (DBM).
Additional material which improves the osteogenic environment can be obtained from bone marrow aspirate which is concentrated for osteoprogenitor cells.
Currently, the most researched treatments include platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and cell-based therapies.
These experiments will also be repeated with hMSCs extracted from fresh bone marrow aspirate and defined under the ISCT parameters.
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