Methylation of CG-rich inlands in regulatory regions of genes marks them for transcriptional silencing.
Three colorful pins stuck on each marks them for teenagers or college students, not Wall Street bond traders.
The sensor of this mechanism, galectin-8 (encoded by LGALS8), detects permeated endosomes and marks them for autophagic degradation, whereas PLA2G16 facilitates viral genome translocation and prevents clearance.
Recently, Feng, Weissman and colleagues demonstrated that activated macrophages secrete calreticulin (CRT), which binds to the surface of viable target cells and marks them for removal by programmed cell phagocytosis (PrCP 1.
"That is the punishment imposed by the cricket authorities," said the judge, "but these crimes of which you have been convicted require that a sentence be imposed which marks them for what they are and acts as a deterrent for any future cricketers who may be tempted.
Rose and his colleagues succeeded in detailing the mechanism for how enzymes are involved in attaching ubiquitin to old proteins, which marks them for destruction.
