Sentence examples for marks on chromatin from inspiring English sources

Initiation of XCI is induced by Xist RNA coating of the Xi (Clemson et al, 1996), creating a silent compartment in which active marks on chromatin are lost and repressive ones are acquired.

The latter is mediated by specific interactions between the modified histone tails and the corresponding enzymes and leads to self-perpetuation of activating marks on chromatin.

We further examined the levels of the histone deposition marks (H4K5ac and H4K12ac) and other histone acetylation marks on chromatin in S-phase cells following treatment with DMSO or 898.

The hyper-recombination observed in BRCC36 depleted cells and the decreased recombination observed in Usp1 (FANCdeubiquitinylasease) deleted cells highlight a central role for different ubiquitin marks on chromatin and repair proteins.

DOI: http://dx.doi.org/10.7554/eLife.06496.010 To further determine whether ORCA is required for the establishment of these histone marks on chromatin, depletion of ORCA (siRNA-mediated knockdowns [KDs]) was carried out both in cancerous cells (U2OS) and diploid fibroblasts (WI-38), and the total levels of H3K9me2 and H3K9me3 were analyzed by immunoblotting (IB).

A new question now emerges: does PARylated Parp1 introduce an epigenetic mark on chromatin?

Acetylation may induce active transcription, while mono, bi or tri-methylation of K27 is associated with a repressive mark on chromatin and gene expression.

A striking example for an epigenetic role of replacement histones is that of CenpA, an H3 variant that has been shown to serve as a self-perpetuating mark on chromatin, important in the maintenance and reproduction of centromere chromatin regardless of its underlying DNA sequence (Cleveland et al., 2003; Bailey et al., 2013).

Recruitment of these complexes deposits repressive histone marks on the chromatin, allowing a transient repressive chromatin structure at the site of DNA damage that blocks transcription and facilitates DNA repair.

We also found that KYP directly associates with the Geminivirus minichromosome and deposits H3K9me2 marks on viral chromatin.

The scanRNAs that do not have cognate sequences in the maternal MAC are transported to the zygotic MAC, where they program DNA elimination, probably through deposit of epigenetic marks on the chromatin.