Sentence examples for marks in gene from inspiring English sources

Again, a DNA-methylation-independent role of chromatin marks in gene silencing was highlighted.

In conclusion, our comprehensive study of H3K9ac and H3K14ac demonstrates a wider role for these to marks in gene regulation than originally thought.

Next, we investigated whether loss of BRD4 and CDK9 from SEs results in reduced levels of elongation marks in gene bodies (GBs) of SE-associated stem cell genes.

We thus suggest, as have others (23, 24), that caution be taken when discussing the role of chromatin marks in gene silencing so as not to imply causality when that information is not available.

While these correlations also hold true for conservation and active marks in gene's upstream region, they are significantly weaker in second introns and negligible beyond the second intron.

Our data show that ATZ changes the number of H3K4me3 marks in genes with a wide range of important cellular functions.

Visual analysis of the profiles suggested a good concordance with previous findings [ 5, 13], showing enrichment of the H3K27me3 mark in gene bodies, intergenic regions as well as promoters and H3K4me3 in gene promoter regions.

Epigenetic states are dynamic and potentially reversible marks involved in gene regulation, which can be influenced by genetics, environment, and stochastic events.

From the chromatin point of view, actively transcribed genes are characterised by Set2-mediated H3K36me2/3 and Dot1l-mediated H3K79me2 histone modification marks present in gene bodies (Nguyen & Zhang, 2011; Venkatesh et al, 2012).

Whereas unicellular eukaryotes, such as yeast, Tetrahymena and Plasmodium principally exhibit modifications associated with transcriptional activation, mammals also employ a wider range of marks involved in gene silencing [ 41, 42].

KRAB suppresses gene expression by altering the histone marks in the gene promoter.