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Although the marks for the study groups were marginally higher than for the non-study groups in both cohorts (usually by 1 2%), these differences were not statistically significant (t-test).
Both figures represent new high marks for the study.
To select histone acetylation marks for the study we used published microarray data from Kurtistani et al.[ 18], which contains acetylation patterns for 11 lysine residues in histones, to find sites that correlate with previously published Gcn5 ChIP-on-chip tiling array data [ 7].
(Mark Twain's lawyer hero, Pudd'nhead Wilson, was so named partly because he was considered a fool for studying "finger marks").
Unlike trials involving dabigatran, rivaroxaban and apixaban, there was marked heterogeneity for studies evaluating ximelagatran (I=79.69; p=0.007).
In this study, the acupuncture points were identified by an experienced licensed acupuncturist, and the three acupuncture points were marked for subsequent study by the same acupuncturist using "cun".
In order to minimize the number of false positive findings, only CNVs identified by two independent algorithms, QuantiSNP and PennCNV [ 28, 29], were marked for further study.
Spikes had to be separated from neighbouring spikes by an interval of >1.5 s to fulfil the criterion for isolated spikes; trains of spikes were not marked for this study.
These estimates would probably also have been biased, because blinding would be logistically challenging in a study, where all study objects need to be carefully marked for further studies.
