Sentence examples for marks for active from inspiring English sources
Recruitment of PHF8 leads to a reduction of the H3K9me2-repressive mark and an increase in the H3K4me3 and H3K9Ac activation marks for active gene expression.
Consistent with the increased occupancy of Cdk9, we also observed increased occupancy of H3k4Me3 (Figure 6B), and a slight increase in occupancy of H3K79Me2 (Figure 6C), both of which represent histone marks for active transcription [45].
Indeed, NM1 gene knockdown led to decreased levels of epigenetic marks for active transcription, including H3K9ac, H3K4me3 and H3K27ac, but did not affect the levels of H3K4me1.
DNase I sensitivity is an indicator of open chromatin, and DNase I hypersensitivity sites are typical marks for active regulatory regions [ 47].
To further characterize the localization of NM1 at the gene level, we interrogated the mouse genome to find out whether NM1 occupancy at class II promoters is compatible with the distributions of Pol II or epigenetic marks for active transcription.
New evidences are accumulating against the convention: histone modifications that mark inactive chromatin are associated with DNA-hypermethylated promoters, whereas histone marks for active chromatin are normally associated with hypomethylated promoters.
Because H3K27ac is a mark for active enhancers, these results indicate that MLL4 is required for the activation of cell-type-specific enhancers during adipogenesis and myogenesis.
At the same time, H3K9me is maximally reduced and H3K4me, the epigenetic mark for active transcription, increases at this stage.
The rapid rise, and critical mass, of consumers using different social networking services — Facebook, the biggest of them all, in October noted that it had passed the 1 billion mark for active users — has had a massive knock-on effect for businesses.
To restrict the analysis to enhancers, we used H3K27ac as a mark for active enhancers [ 33].
Especially H3K4-trimethylation (H3K4me3), a mark for active gene promoters, has been studied.
