Sentence examples for marks at imprinted from inspiring English sources

Comparing the enrichment patterns of these marks at imprinted genes to all other genes within the mouse genome highlights whether imprinted genes are epigenetically regulated in a unique manner.

Thus, the heightened vulnerability of the BN/SD strain to fetal weight deficit could result from alcohol-induced alterations of epigenetic marks at imprinted loci.

Moreover genetic and molecular studies of the development and evolution of sexual dimorphism [66] have shown that epigenetic marks at imprinted gene DMRs are established in a sex-specific manner in bovine blastocysts, after somatic cloning [67].

These data demonstrate that wildtype and heterozygous male germ cells have appropriately erased methylation marks at imprinted loci at E13.5, whereas erasure is delayed, or completely stalled, in Dazl−/− mutant germ cells.

Nico Ruf (Babraham Institute, UK) presented evidence that transcription is required for establishment of maternal germline methylation marks at imprinted genes.

In all cases, the global methylation status of our samples was not detectably altered suggesting that the DNA methylation marks at imprinted loci are more readily altered.

In support of the concept that loss of DNA methylation could be a common association of loss of H3K4 demethylase activity, mouse oocytes deficient in the H3K4 demethylase Kdm1b demonstrated a global increase in H3K4 di-methylation and failed to generate normal DNA methylation marks at several imprinted loci [ 68].

Instead, these two marks are exclusively enriched at imprinted genes possessing promoter DMRs, the majority of which are germline DMRs, consistent with imprinting control.

Nevertheless, this is the first study in metatherians that demonstrates the presence of histone modifications at imprinted loci and suggests that they could serve as the "primordial imprint mark" in the absence of differential methylation.

While it can now be concluded that parent-specific DNA methylation is an epigentic mark common to Marsupialia and Eutheria, the molecular mechanisms of transcriptional silencing at imprinted loci have clearly evolved along independent trajectories.

Cooper WN, Khulan B, Owens S, Elks CE, Seidel V, Prentice AM et al. DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial.