Sentence examples for marks are lost from inspiring English sources

In MSC and ADSC repressive histone modification marks are lost.

As shown in figure 2, H3K27me3 marks are lost from the RD element in senescent cells and from the shared exon 2 in senescent, Bmi1−/− and M33 mutant MEFs.

In the growth disorders, germline allele-specific methylation changes have the effect of an imprint switch so that both alleles look like either a paternal allele (BWS) or a maternal allele (SRS) while in cancer both parental marks are lost and reprogrammed.

First we consider the mechanisms by which euchromatic marks are lost from the Xi.

In line with this idea, upon Cdk1 inhibition, the H3-T3 and H2A-T120 phosphorylation marks are lost, most likely due to the activity of PP1γ phosphatase (van der Horst and Lens, unpublished data) (Qian et al. 2011; Vagnarelli et al. 2011).

ChIPseq analysis revealed that the Igf1 locus was strongly marked with H3K27me3 marks in control animals but those marks were lost in Shh-cre Ezh2 Shh-cre Ezh2(fl/fl6A, FDR=0.0003).

Our RNA-seq data showed that Dkk1 was overexpressed in Ezh2-deficient epithelial cells (3.5-log2 fold increase, FDR<0.001) and that H3K27me3 marks were lost on the Dkk1 promoter of Ezh2-deficient lungs (supplementary material Fig. S5A, FDR<0.001).

Surprisingly, after loss of expression of the targeted methyltransferases, the induced epigenetic marks were lost over several days and the VEGF-A gene was reactivated to its original level.

In patient-derived cell lines, the mat/pat asymmetric distribution of these epigenetic marks was lost with H3K9me3 and H4K20me3 becoming biallelic in the BWS and H3K4me2, H3K27me3 and H3K9ac together with CTCF cohesin becoming biallelic in the SRS.

Although we detected only H3K9me2 mark on the body of actin, which was reduced after stress (P < 0.001, Fig. S4C ), immunoprecipitation with the same antibodies effectively captured all the studied methylation marks in the chromatin wrapping the transposon; however, these marks were lost as a result of water stress (P < 0.05, P < 0.01) (Fig. S4 ).

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