Sentence examples for marks are established from inspiring English sources

In the event of X chromosome inactivation, robust epigenetic marks are established in a long noncoding Xist RNA-dependent manner, giving rise to a distinct epigenetic landscape on the inactive X chromosome (Xi).

Elucidating how DNA methylation marks are established in the germline has been a challenge for nearly 20 years, but represents a key step towards a full understanding of several biological processes including genomic imprinting, epigenetic reprogramming and the establishment of the pluripotent state in early embryos.

New DNA methyl marks are established over many stages, extending through sexual maturity in accordance with the sex of the developing individual.

DNA methylation marks are established mainly during early life, and although thought to be a fairly stable measure, DNA methylation has been associated with aging (Madrigano et al. 2012).

This disparity might suggest fundamentally different mechanisms by which DNA methylation marks are established in the male and female germlines and/or differences in how oocyte- and sperm-derived methylation is treated after fertilisation in the zygote.

This may be reconciled if we assume that gene silencing in LoDs is complete when both DNA methylation and H3K9me2 marks are established, but is derepressed in the absence of DNA methylation.

The Co-operative launched the UK's first own-label Fairtrade wine in 2000 before the mark was established.

The previous shortest mark was established as long ago as 1972 when Jack Nicklaus arrived at Muirfield for the Open championship holding three of the four majors.

But when Johnson, on that electrifying Georgia night in 1996, settled into his unique shoulders-back style and persuaded his legs to whirr to a record of 19.32 for the 200m, a mark was established that might as well have been sealed in a lead casket and buried in an unmarked tomb.

We assess a growing body of literature, including treatment of how the mark is established, the patterns of methylation, and the functional consequences of this epigenetic signature.

The H3K27Ac mark is established by CBP/p300 acetyltransferase [ 13, 14] and is likely erased by RBP3/HDAC1 [ 15].