This analysis reveals a marked and specific impairment of microtubule dynamics in spastin-mutant cortical axons.
The marked and specific reversal of oxaliplatin-induced cell death by DL-TBOA suggested that an oxaliplatin import mechanism might be inhibited by DL-TBOA.
Intradermal administration of BoNT‐A to healthy volunteers produced a marked and specific decrease in noxious mechanical pain sensitivity, whereas sensitivity to low‐threshold mechanical and thermal stimuli was unchanged.
Inhibition of Smad7 was associated with arrest of CRC cells in S phase of the cell cycle and a marked and specific downregulation of CDC25A, a phosphatase that controls progression of the cell cycle through the S phase via the dephosphorylation CDK2 and inhibition of CDK2 cyclin complex activity.
Our analysis reveals an early, marked and specific impairment of microtubule dynamics in spastin-depleted cortical axons, which is associated with a major disorganization of the microtubule network within the swellings that alters retrograde axonal transport by increasing the frequency of cargo stalling.
"This is a starting point from which I can start broadening evocations, through the treatment of my materials, the mark making, and specific decisions in abstracting, cropping, and layering the sources to discuss a more personal narrative".
As suggested in a recent review [ 90], it is essential to explore other vertebrate lineages for epigenetic marks and allele-specific expression.
Phenotypic modulation is associated with specific gene expression which could be regulated by epigenetic marks, chromatin remodelling, and specific SMC transcription factor binding.
We are only beginning to understand the functional significance of 5hmC as an epigenetic mark and the specific roles of the three Tet enzymes.
Although multiple tissues showed marked autolysis, distinct and specific IHC staining for N. meningitidis serogroup C was identified within blood vessels and in neutrophilic infiltrates in the leptomeninges (3, 4 ).
