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Suva et al recently showed that CD133 expression marks a population of Ewing's sarcoma cells with tumor initiating activity [30].
An important conclusion from our study is that CD133 mainly marks a population of E/M hybrid cells, which is adaptable to different conditions and able to differentiate into either epithelial or mesenchymal cells depending on the provided environment.
A recent study has demonstrated that LGR5 marks a population of cancer stem cells (CSCs) within mouse intestinal adenomas (Schepers et al., 2012).
Based on our observation that FoxA marks a population of irradiation-sensitive pharynx progenitors, we wondered if any or all of them were smedwi-1 + stem cells.
While not a predominant mutation in glioblastoma multiforme, the increased prevalence of BRAF V600 mutations in pediatric CNS tumors and certain subtypes marks a population to whom this therapy could be applied.
Survivin, an IAP protein with the ability to both block apoptosis and regulate cell cycle, almost exclusively, marks a population of normal human keratinocytes with stem cell characteristics (Marconi et al, 2007).
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We show that ENG expression in FLK1+ cells mark a population of cells with early hemogenic and hematopoietic potential.
Early data suggested that Blimp1 specifically marked a population of sebaceous gland stem cells (Horsley et al., 2006).
These results suggest that ALDH may mark a population of cardiac-resident, MSC-like progenitor cells that possess superior ex vivo growth characteristics.
The results presented so far demonstrate that Sox2 is essential for osteoblast self-renewal and suggest that its expression may mark a population of uncommitted or unipotent osteoblasts.
This gene has recently been shown to mark a population of adipocyte progenitors but has not yet been linked functionally to MaSCs [ 48].
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