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Clearly, more effort is needed to find alternative, more universal nuclear markers with sufficient discriminatory power.
Markers with sufficient sensitivity and specificity to offer clinical utility have been sought for cancers [12], tuberculosis [13], transplantation [14], eclampsia [15] and autoimmunity [16].
Firstly, markers with sufficient sensitivity and specificity for the other histological subtypes need to be found.
The success of any association study depends on the selection of SNP markers with sufficient genetic informativeness, as discussed above.
Therefore, a high-density genetic linkage map for walnut is required that comprises a large number of markers with sufficient sequence information.
However, because of the lack of a large number of molecular markers with sufficient sequence information, many QTLs for target traits cannot be accurately detected.
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Currently, the only marker with sufficient evidence to justify routine clinical assessment is KRAS mutational analysis for EGFR-specific therapy decision-making [ 6].
The more detailed linkage map with sufficient markers is necessary to be feasible for QTL identification and marker-assisted selection.
However, a more detailed linkage map of all chromosomes and with sufficient markers is necessary to be feasible for QTL identification and marker-assisted selection.
This finding supports the contention that most of the cross-species markers can be measured with sufficient analytical accuracy for use in additional studies.
The time for predictions that with sufficient markers the three prototypical conditions (schizophrenia, bipolar or manic-depressive disorder and unipolar depression) will each be found associated with specific chromosomal loci is long past.
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