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Therefore our strategy of investigating individuals with well-defined statin-induced mitochondrial defects during a randomized trial allowed us to identify markers with potential diagnostic and prognostic value.
With the exception of three genes (MMP12, S100A7 and SPP1) whose expression requires further validation, we were unable to find markers with potential utility for the detection of aggressive disease.
In both hematologic malignancies and in RCC, it was reported that the variation in gene expression between patients with disease and healthy controls was much greater than the inter-sample variation observed for the healthy patients alone, suggesting that PBMCs could be useful surrogate markers with potential diagnostic and prognostic applications in cancer.
Novel tumour markers with potential clinical utility are thus awaited.
The present review focuses on newer markers with potential prognostic impact for the disease.
Such findings may enable future research to be targeted at genetic markers with potential prognostic significance.
Similar(41)
Nuclear MBP-1 appears to be a novel and valuable histochemical marker with potential prognostic value in breast cancer.
Notably, EZH2 may serve as a novel marker with potential for clinical oncology.
The ALDH1A3 isoform has been reported to be a novel CSC marker with potential clinical prognostic application in breast cancer [ 34].
These findings provide the emerging physiologic evidence in support of the role of FATS as an E2-independent E3 toward p53, in addition to pinpointing a genetic marker with potential value in predicting breast cancer risk in women with parity ≥3.
The H5N1 Genetic Changes Inventory (5 ) was used to screen NA and M gene alignments for molecular markers associated with potential drug resistance.
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