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Under this assumption, the increase in the genetic selection differential is largely due to changes in allele frequencies at markers with large effects.
Our result suggested that designing a low-density chip by selecting low frequency markers with large SNP effects sizes should be helpful for commercial application in Chinese Simmental cattle.
For a battery of tightly linked anonymous genetic markers spanning a candidate region centered around a disease locus, simulation methods based on a coalescent process with mutation, recombination, and genetic drift were used to study the spatial distribution of markers with large noncentrality parameters in a case control study design.
At 5% type-I error rate, only 4.65 markers were expected to be significant by chance, indicating the existence of an excess of markers with large differences between both samples (χ2 test p = 0.0375).
The rule of thumb is to select markers with large allele frequency differences between ancestry populations.
However, not all X chromosome markers with large AFD were highly significant.
Similar(33)
Across all brain regions, CPF exposure evoked significant reductions in both markers, with larger effects on HC-3 binding, which is responsive to neuronal impulse activity, than on ChAT, a constitutive marker.
Table 2 summarizes the combined effect of the 100 markers with largest effects for each trait.
Thus, including markers with larger amounts of missing data led to improved GS accuracies.
The 100 markers with largest effects identified 76 regions of which 36 were within QTL of interest.
Among the 100 markers with largest effects there were 77 regions of which 33 within QTL of interest.
More suggestions(15)
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