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Markers with frequent variants captured greater than 30% of the phenotypic variation in this population in both datasets.
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Particular attention should be paid to patients with radiological stage I disease and elevated tumor markers: patients should be monitored with frequent post-orchiectomy serum marker determinations until complete marker normalization before these patients are classified as having true stage I disease.
Clinical reports suggest these are markers of biologically aggressive carcinoma with frequent lymphatic vessel invasion in TURB specimens and lymph node metastasis [ 6, 8, 21].
By the use of the latter markers, we could separate CIMP-high tumors (with frequent BRAF mutations) from CIMP-low tumors (with frequent KRAS mutations).
However, combining the genotype information for this marker with the more frequent IL13 marker, which is also more significant (Mantel Haenszel Pcombined = 0.00015), resulted in two common psoriasis-associated haplotypes that were both highly significant.
Recent studies proposed GDF15 as a prognostic marker for ovarian and pancreatic carcinoma [ 41], two types of malignancies with frequent aneuploidy and chromosomal instability [ 9].
First, it is highly regulated, with frequent routine and ad hoc State and Federal oversight; treatment adequacy markers must be reported.
Thirteen microsatellite markers, which were mapped to and/or very close to the tumor suppressor genes or regions with frequent LOH in breast cancer, were used.
Plan short trips with frequent stops.
Build a relationship with frequent contributors.
Mutations of the NRAS protooncogene are the most frequent so far identified molecular markers with variable incidences of 10 66% in this entity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com