Because only a small tissue sample of each tumour is punched on an array, the question has arisen about the representativeness of TMA when studying markers that are expressed in only a small proportion of cells.
Considering cost-effectiveness trade-offs, Cytb appears as a proper molecular marker to be chosen when studying phylogenetic relationships, at inter- and intraspecific levels in Cyprinodontiformes, as was frequently used by Murphy and Collier [ 84, 85] and García et al. [ 6, 7] as well as in other highly related Rivulidae genera [ 86].
The best characterized transposons are those of the Ac/Ds family, which were first discovered in maize by Barbara McClintock when studying phenotypic markers of maize germplasm [ 60].
However, the findings presented here emphasize the relevance of molecular characterization of colon tumors for MSI status as a factor that may influence prognosis, in particular when studying novel markers with potential prognostic value.
Thus, leg length may be a useful marker of early childhood conditions when studying the impact of early life deprivation on adult disease risk.
Owing to data limitations differences in uPAR levels were not studied according to adenoma type or size, variables that are indeed of great interest when studying potential screening markers in CRC.
Knowing the joint marker status of each cell would permit the modeling of markers as a multivariate binomial random variable, and thus allow us to assess correlations between the presence of different markers, which might be particularly important when studying various kinds of mutant strains in which the timings of cell cycle events have been disrupted or shuffled.
Moreover, when studying the iron metabolism in relation to cancer, it is important to take markers of inflammation into account.
Concentrate when studying.
When studying, study it the right way.
