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However, this circumstance does not hinder the use of non-validated surrogate markers when deciding upon the most promising drug candidates in early stages of drug development.
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Each of these exhibit slightly different advantages and disadvantages but there are three main considerations when deciding which genetic markers to use in linkage map construction: (i) the markers need to be polymorphic, (ii) they need to be evenly spread across the genome or region of interest and provide dense marker coverage, and (iii) they must have a low genotyping error rate.
when deciding on disciplinary actions.
This marker combined with other prognostic events such as size larger than 1.5 cm, location [ 28], or presence of microcalcifications [ 42] can assist when deciding the possibility of an aggressive treatment versus a conservative follow-up.
Difficulties arise when deciding how to handle in-hospital mortality.
The situation is more complicated when deciding about specific interventions.
When Roger decides to kill Piggy?
That was when they decided to marry.
That was when Andre decided to change.
He went when he decided to go".
That is when they decide to go".
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