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After determining which genetic markers were most strongly associated with lifespan, they applied that knowledge to DNA samples from another set of individuals.
Cells expressing lineage specific markers were most abundant in the MID, LOW, and NEG populations; only a small minority of HIGH cells expressed lineage specific genes (Figure 3b).
Interestingly, in the Kumar classification, the immunological markers were most severe in patients with ABPA-CB and not ABPA-CB-ORF.
Vaccination-induced changes of these markers were most pronounced in the draining LN.
The reason why two alleles per markers were most frequent was that they might include STS markers.
The GNMS markers were most polymorphic in the intronic region (73.3%) followed by markers in the promoter region (53.3%) and least in the CDS (26.6%).
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This difference between 110 and 208 markers is most likely due to the predicted double crossovers that are more likely to be detected as marker number increases.
It is in these target populations that serum markers are most urgently needed.
One of the cancers for which new prognostic markers are most urgently required is prostate cancer.
It is in these target populations that molecular markers are most urgently needed.
Over the coming years, longitudinal studies should establish which of these markers are most effective.
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