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To monitor the bone formation over time, fluorochrome markers were administered at 3, 5 and 7 weeks and the animals were sacrificed at 9 weeks after implantation.
Enteral markers were administered only if the patient was documented to be tolerant of enteral nutrition.
When the markers were administered 2.5-3.0 2.5-3.0, chapart in T/B ratios of 8-25% were observed in 10 out of 28 (36%) tumours.
The following study markers were administered concurrently: sinistrin 2,500 mg (Inutest; Laevosan, Linz, Austria), p-aminohippuric acid (PAH) 440 mg (4% p-aminohippuric acid sodium salt; CFM Oskar Tropitzsch, Marktredwitz, Germany), rac-pindolol 5 or 15 mg (Barbloc; Alphapharm, Millers Point, NSW, Australia) and fluconazole 100 mg (Diflucan; Pfizer Australia Pty Ltd, West Ryde, NSW, Australia).
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EF5, a hypoxia marker, was administered 3 h before being killed.
When markers labelled with both radioisotopes were administered simultaneously to EMT-6 tumour-bearing scid mice, T/B ratios were found to vary by up to 300% between different tumours, with an average intratumour variation of only approximately 4%.
Meropenem, vancomycin, and voriconazole were administered, but his remittent fever and high concentrations of inflammatory markers (CRP 15.52 mg/dL, PCT 0.78 ng/mL) persisted.
Questionnaires were administered physically.
Recipient mice were administered i.t.
were administered every 12 hours.
Drugs were administered intraperitoneally (i.p).
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