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However, a moderate LD (R2 = 0.45) was observed between the two single SNPs (Additional file 6: Figure S3c), suggesting that the significant effect of both markers was due to the same causal variant.
However, the possibility that the reduction of glial markers was due the bias of neuronal differentiation cannot be ruled out.
Only one out of 7 failed markers was due to plate super pool deficiency.
Only 6.7%% of genetic variation revealed by ISSR markers was due to differences between individuals within sampled sites.
This low proportion of usable markers was due largely to the presence of sequences which, though unique in the assembly, were present in multiple copies in the genome.
To determine whether the lack of pro-inflammatory markers was due to the age of the APPSw mice, we also measured mRNA changes for IL6, TNFα, IL-1b, CAT2 and MARCO in 12- and 106-week-old control APPSw mice.
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Based on these observations, it is possible that the varied trait association potential estimated for TFGMS and TFFDMS markers are due to their presence in different TF genes.
Cross-species transferability of EST-derived genic markers is due to the conserved nature of primers picked up from coding sequences.
The small number of appropriate markers is due to the fact that WAG and OXYS inbred strains are barely polymorphic at the majority of known microsatellite marker sites in their genomes.
Whether these relatively low rates of success in the development of effective markers were due to problems with PCR amplification or to fixation of the markers once amplified is unclear.
Expression of the progenitor cell marker dome-MESO-lacZ (D ) is strongly reduced in bip1 RNAi lymph glands (D′ ), demonstrating that the gain in differentiation markers is due to the loss of progenitor cells that normally express dome-MESO-lacZ.
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