Whether PA could serve as a valid diagnostic marker to segregate acute from chronic hepatitis C remains to be determined.
Importantly, it is possible for a marker to segregate as a single locus in one population, but as a different locus in another population.
In the case of markers known to segregate male and female [ 8, 21], we used all markers that clustered with markers on scaffolds known to segregate with sex (see above).
Only markers informative for a given prediction approach were considered for computing A. Consequently, markers had to segregate (always meaning MAF > 0.05) in at least one heterotic group for the "combined" prediction approach, in both heterotic groups for the "across" prediction approach and in the corresponding heterotic group for the "within" prediction approach.
While the bilayered ductal system is not fully established until after birth, basal and luminal markers began to segregate during late embryogenesis.
Both MI and FI markers were expected to segregate in a 1 1 ratio, whereas the BI markers, which were heterozygous in the parents, segregate in a 3 1 ratio.
Five specific markers enabled us to segregate micro- and macro-follicular adenomas from oncocytic adenomas and minimally invasive follicular carcinomas, while only one of the six cross-validated markers showed the same performance.
By mid-week 8 (CS21), these markers had begun to segregate such that, although most TEC expressed K8, K5 was more highly expressed by cells along the midline of the thymic lobe and in some scattered cells (Fig. 3B-B″).
While there may be no causal link between the differentially expressed genes and their associated traits, they do provide an excellent starting point for development of DNA markers linked to segregating traits of interest.
Using a subset of these mapped SSR markers to screen segregating populations will allow QTLs to be mapped on intervals of the genetic map, and fine mapping can be carried out using markers from BAC end sequences or WGS sequences within an interval.
