The number of unlinked markers required to discern unrelated individuals from those with closer relationships is on the order of a few hundred markers (Roberson and Pevsner, in preparation).
Because AIMsFinder infers the minimal number of markers necessary to discern two genetically distinct populations, it was applied in a pairwise fashion over all the population data sets.
However, autosomal-driven studies attempting to discern markers informative to genetic anthropology from those having medical relevance often met with legal or ethical obstacles and failed to attract participants who remained concerned about the sharing and potential exploitation of their medical information (Royal et al. 2010).
AIM panels with a small to moderate number of genetic markers have been constructed to discern samples from different populations, including Europeans [ 12], East Asians [ 11], African Americans [ 17], and European Americans [ 3, 19], and different continents [ 2, 4, 5, 9, 16] at a more reasonable price.
However, when estimates were based on fewer markers, or less informative markers, it was often impossible to discern discrete genotype clusters by generation 2 (e.g., see Figures 5 and 6).
These analyses provide supportive evidence that this chemoresponse assay is a predictive marker, demonstrating its ability to discern specific therapies that are likely to be more effective among multiple alternatives.
The current study sought to address whether this chemoresponse assay could function as a predictive marker, with the capacity to discern specific therapies that are likely to be more effective and those that are not.
The results provide reasonable evidence that this assay is a predictive marker, with the capacity to discern specific therapies that are likely to be more effective, and women with recurrent EOC may benefit from assay-informed therapy selection.
Studies utilizing human complement and/or EC in vitro have endeavored to discern better markers of early complement activation (69, 70).
Notably, besides the above mentioned properties (self-renewal potential and ability of multilineage differentiation), GBM-derived CSCs share a crucial feature with neural stem cells: the expression of distinctive stem/precursor markers that can be helpful to discern them from non-CSC populations within a tumor.
