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When the assay was combined with these conventional tumor markers, the sensitivity increased to 78%%.
For all the other tested tumor markers, the sensitivity and specificity rates were lower.
For other markers, the sensitivity analysis did not indicate high stability of the results due to one or two studies.
By combining IRF8, p14 and SFRP1 together as a panel of methylation markers, the sensitivity and specificity of a sample showing methylation of one of these 3 genes was 86.7% and 94.7%, respectively (Table 5).
For the continuous distribution markers, the sensitivity and specificity can be calculated as follows [ 10], Sensitivity = P Y D > c = Φ μ D - c σ D ; Specificity = 1 - P Y D ¯ > c = 1 - Φ μ D ¯ - c σ D ¯, where D ¯ indicates non-disease group, and c is the threshold above which a positive (disease) call will be made.
However, when using the multimarker assay (positivity is defined as positivity for at least one of the markers), the sensitivity was improved to 56% (53 out of 94), which was higher than other similar studies (Pierga et al, 2008; Daskalaki et al, 2009; Xenidis et al, 2009; Chen et al, 2010; Krishnamurthy et al, 2010); meanwhile the specificity was 95% (38 out of 40).
Similar(54)
Using this marker, the sensitivity increases according to tumor stage [ 107]; CEA levels decrease after tumor resection.
12 As a diagnostic marker, the sensitivity and specificity of serum CRP for discriminating bacterial from non-infectious inflammation were only 75%and67%7%, respectively, according to a meta-analysis.
Firstly, the panCTC gene panel included a cocktail of eight epithelial markers, increasing the sensitivity of detecting epithelial marker expression.
Third, due to the distinct expression characteristics of AFP and annexin A2, the combination of both markers enhanced the sensitivity and specificity, indicating that these two markers are complementary.
The combination of these markers enhanced the sensitivity further.
Related(20)
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