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For these two biochemical markers, the ability to predict CAP was evaluated by a ROC curve.
Importantly, the de novo-created CD133+ subpopulations are truly CSCs, as also defined by their cell-surface markers, the ability to form spheres, and the increase in radioresistance (similar to Figure 2).
If the identified TFs are to have any utility as clinical markers, the ability to differentiate healthy controls and patients with benign conditions from patients with early-stage disease (as opposed to advanced-stage disease) is essential.
Apart from flow cytometry analysis of stem cell markers, the ability of tumor cells to form mammospheres (spheres of cells formed under ultra-low attachment conditions, in serum-free media supplemented with growth factors) as a surrogate assay of the stemness of the cells has been described [ 13, 14].
Although iPS cells exhibit a unique gene expression signature (15), they resemble embryonic stem (ES) cells in many respects, including the expression of pluripotency markers, the ability to differentiate into cell types that represent all three germ layers, and to contribute to chimerism and teratoma formation in mice.
The isolation of TICs is based on the expression of specific cell surface markers, the ability to pump out Hoechst dye (referred as "side population" or the cells that do not retain the dye), the high aldehyde dehydrogenase 1 activity or the ability to grow in vitro as unattached spheroids in an appropriate medium [ 2].
Similar(54)
Based on our results, penta- and hexanucleotide STR markers surpass tri- and tetranucleotide markers in the ability to distinguish Y chromosome haplogroups without SNP data (Figures 1 and 2).
Compared with mapping with recessive markers, the use of dominant markers offers the ability to reduce the number of generations and crosses required to estimate genetic map positions.
Precise molecular markers have the ability for influencing high-throughput genome sequencing and the characterization of the genetic diversity for the crop species.
Cells were immunoreactive to the pluripotency markers, demonstrating the ability to maintain pluripotency of the investigated stem cells on chip.
We also investigated linkage disequilibrium since the extent of correlations between markers determine the ability to detect selection acting on nearby regions.
Related(20)
marks the ability
gauges the ability
parameters the ability
identifiers the ability
labels the ability
traces the ability
markers the rank
markers the risk
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markers the consensus
markers the state
markers the allele
markers the tip
markers the man
markers the marker
markers the linkage
markers the judge
markers the size
markers the prediction
markers the percentage
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