Alternatively, they could follow reprogramming cultures (on dox) at different time points (e.g., day 3, 6 and 9 would be informative) for markers that reflect distinct stages of iPSC formation.
Similarly, the distributions of markers that identify anatomically distinct subpopulations of neurons such as calbindin (Supplementary Fig. 1c, d) or non-phosphorylated neurofilament (Smi32-epitope, data not shown) were indistinguishable in Ercc1 Δ /− and wild-type mice.
Lead in plasma or serum (Cake et al. 1996) has recently received attention as a biological marker that is distinct from whole blood lead and that by virtue of representing the fraction of lead in blood that is most biologically available to cross cell membranes such as the placenta may be better at predicting some forms of toxicity than whole blood lead levels (Hu et al. 2006).
Macrophages are heterogeneous and can be classified by distinct phenotypic markers that correspond to different subsets with distinct functional capabilities, including important roles in tissue repair and remodelling [ 17].
This was likely due to the presence of tightly-linked markers that are revealed by distinct clones.
Furthermore ARTD10 did not co-localize with a number of distinct markers that included GM130 (for Golgi), CFP-ER (for ER), Rab5 and EEA1 (for endosomes).
Using estimates of the resolution parameters above, we can compute the theoretical proportion of markers that can be assigned distinct positions in RH maps (Additional file 7), using three assumptions: (i) the RH order is the true order (ii) markers are evenly spaced on the genome and (iii) RH vectors have no missing data or genotyping errors.
Moreover, although recent studies have defined molecular markers that are uniquely expressed in distinct DA neuron progenitor domains, the lineage relationships between spatially distinct progenitors and different DA neuron subtypes remain unclear.
The neurobiological markers that discriminated each contrast were distinct.
Given a panel size and resolution parameter, Additional file 7 provides the equations allowing to derive the expected number of markers that can be mapped to distinct positions.
