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However, the markers that confer power are also potentially problematic as they can be cumbersome, risk phenotypic effects of the inserted genes, and accumulate as unwanted genes during successive mutagenesis cycles.
Thus, there is a crucial need to find genetic and immunologic markers that confer increased susceptibility to progression.
These have still however only revealed markers that confer relatively small increments of risk and only explain a small proportion of the observed familial clustering of common diseases.
Prospective prediction of invasive versus in situ breast cancer will require more sophisticated and accurate models, inclusion of consecutive cases of both benign and malignant diagnoses, and development of improved predictors, possibly molecular markers that confer invasive risk [ 32].
The CQ use data have not been analyzed in light of molecular markers associated with CQ resistance because, at this time, a comprehensive database of molecular markers that confer resistance to CQ is yet to be completed.
Given their specificity for type 1 diabetes [ 6], however, this does not detract from their well established value, in combination with other autoantibodies, in assessing risk of the disease [ 6, 10, 20], but does illustrate how useful biomarkers need not necessarily have associations with genetic markers that confer susceptibility to disease.
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Although the presence of a coloured marker is easier to recognise, the presence of a selectable marker that confers resistance to a drug facilitates selection of the recombinant viruses.
The inducible form of HSP70 (HSP72), a repair protein and tissue stress marker that confers protection against ischemia and preserve cellular functions [ 92], was increased in only 12-week HRHF muscles and tendons.
We followed a similar strategy here and modified the previously published vectors pCGEN, pCHYG, pCAMB-BAR (Kramer et al., 2009; Motteram et al., 2009, 2011; Perez-Nadales et al., 2014), which carry different dominant selectable markers genes that confer resistance against hygromycin, geneticin and Basta, respectively.
Live attenuated marker vaccines that confer effective protection against the disease and allow differentiation between infected and vaccinated animals (DIVA) could impact CSF control policies.
The strains ypr013cΔ and ypr015cΔ are MATa yeast deletion mutants, each carrying a gene deletion linked to a kanamycin-resistance marker kanMX that confers resistance to the antibiotic geneticin (G418).
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