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Armed with validated SNPs and haplotype markers that associate with adverse drug reactions, clinicians could perform screening tests and, if indicated, choose alternate therapy.
In support of this, a number of studies have identified further biologically relevant markers that associate either with a particular subtype or reveal heterogeneity within a subtype.
Adaptive genetic markers that associate with migration potential in a migratory species open the possibility for predicting how individuals may distribute themselves across their range prior to their migration.
Unlike Mendelian disorders, however, which can often be traced to mutations that disrupt gene structure or coding sequences, genetic markers that associate with complex disorders often map to chromosomal sites located outside of gene coding regions [ 8].
Additionally, other markers that associate with putative committed progenitor cells of the gut, brain, and eyes are also enriched in this cell fraction (hnf4, chat, and sp6-9, respectively) (Wagner et al., 2011; Lapan and Reddien, 2012; Cowles et al., 2013; Scimone et al., 2014).
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Therefore, the markers that associated with severe dengue in the univariate analysis were included in the multivariate analysis.
The purpose of this study is screening SNPs markers that associated ICA stenosis by oligonucleotide-based custom DNA array.
As CD133 and EpCAM were the markers that associated with post-TACE status, we wanted to determine if variable expression of these markers predicted tumor characteristics.
The probably polymorphic markers that associated with the trait were used to genotype the 135 homozygous recessive individuals from the F2 population firstly.
For these combinatorial traits, we detected 20 markers that associated with trait ratios involving iron concentration at a genome-wide significance level.
Whereas traditional statistical methods are employed to identify the marker that associates the most with an observed phenotype, Markov logic networks can be used to identify a subset of markers that predicts the phenotype.
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