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The ESR1 and PGR markers tested in MM showed no significant association in the present study, despite previous association with migraine without aura [24 26].
The selection of genetic markers tested in this study was based on the availability of sequences for these markers for all Thunnus species together from previous phylogenetic studies.
The results for all serological markers tested in the samples and for the statistical analysis according to three analyzed variables (sex, age group and geographical origin of the samples) are shown in Table 1.
Eight of the 11 candidate markers tested in the filtering set showed a linear relationship between the ratio of EOC patient serum to control serum in the samples and the signal measured in the corresponding ELISA assay, while three of the candidate markers (TACSTD1, AMH, IL13RA2) showed no consistent relationship between these values and were not evaluated further.
The more conservative Bonferroni correction of the P values, accounting for all markers tested in this study (P<0.05/50), would consider ten of the fourteen loci significant (1p36, 1p31, 3p22, 5q14, 7p14, 7q21, 8q24, 11p15, 13q14 and 16q24) and sixteen loci nominally signficant.
Among the four markers tested in our data set, only one marker, PICALM (rs3851179) showed nominal significant genotype effects on the change in CDR-SB over time for AD subjects (p = 0.02, Bonferroni adjusted p = 0.08), with the TC genotype showing a greater increase than either the TT or CC genotype.
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Remarkably, all markers tested earlier in the mouse system showed similar expression patterns in human teratomas.
We infer that TQ Green that did not colocalize with any of the organelle specific markers tested resides in cytoplasm.
For all markers tested, the expression in RYAS41 cells was in the same range as the one found in 832/13 INS-1 cells (Fig. 4B).
The full set of markers tested is shown in Table S1.
The results of the markers tested are presented in Table S2.
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