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This limits our ability to evaluate multiple markers simultaneously in a multivariable model.
The test was able to screen numerous markers simultaneously in 5 h.
Instead of relying on a two-step multilevel model, we may alternatively estimate the temporal trend and effects of markers simultaneously in one linear mixed effect model (BLMM).
Our approach on the other hand, is able to reduce the problem of correlations by analyzing all markers simultaneously in a linear regression framework.
To accomplish this is task, the use of multiple markers simultaneously in the analysis of FCM data will help a lot.
The ability of high-throughput genotyping technologies to interrogate millions of markers simultaneously in association studies necessitates the use of large sample sizes that can be recruited only through collaborations; some studies reported at the meeting included > 90,000 participants.
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Studies in human subjects that have measured diet-induced alterations in gut metagenomic and whole-body metabolic markers simultaneously have shown that modifications in the microbiota are accompanied by improvements in glucose homeostasis and lipid metabolism.
The other two methods involved fitting all markers simultaneously as random effects, modeled in a Bayesian framework [ 21].
Because SAA, an inflammation-related marker, and PON1, an antioxidant marker, have relatively clear opposite characteristics among the HDL-associated proteins, the approach of assessing the two markers simultaneously may provide new insights in clinical practice.
In particular, because the modeling approach uses information from all markers simultaneously rather than pair-wise as in manual gating, it can often identify false negative and false positive events that are not easily discriminated in any two-dimensional projection.
Prediction of genetic risk derived from pre-selected marker variants is mainstream in this domain, as opposed to prediction based on fitting whole-genome markers simultaneously, as done with great success in animal and plant breeding [ 8- 11].
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