Initial studies reported here demonstrate that both fluorescent markers show normal Mendelian inheritance and that expression of the effector gene does not have a significant impact on wing length or development during normal husbandry.
Despite the overall disruption to epithelial organization in the developing tubules, immunolabelling with the apical membrane marker aPKCζ showed normal apical localization of this protein on the luminal side of tubules in both WT (Fig. 2G) and homozygous kidneys (Fig. 2H and I).
Furthermore, whole-mount in situ hybridization analysis of BMP4 transgenic lungs using probes for the proximal airway marker, CC10, and the distal airway marker, SP-C, showed normal AT-II differentiation of bronchiolar Clara cells but a reduction in differentiated cells, indicating that BMP4 plays an essential role in the alveolar epithelial differentiation [ 71]. (1) GATA-6 Transcription Factor.
In one small study, all coronary angiograms in 20 patients with elevated cardiac markers following CO poisoning showed normal coronary arteries [ 42].
Blood examination showed normal tumor markers (squamous cell carcinoma, 1.1 ng/dl, carcinoembryonic antigen, 5.2 ng/dl, carbohydrate antigen 15 3, 9.6 ng/dl) and normal liver function.
Flanking markers nf2C3.1 and nf2CAV, however, showed normal retention of the paternal alleles in the myoepithelioma of this patient.
Muscle biopsies showed myopathic changes, whereas immunohistochemistry showed normal expression of marker proteins for muscular dystrophies.
Laboratory tests performed at admission showed normal levels of inflammatory markers and normal neutrophil counts.
Three of the 26 recurrent patients (11.5%) showed normal serum levels of all tumour markers.
Among the 160 patients with primary tumours, 104 (65%) showed normal serum levels of all tumour markers and 46 (28.8%) had elevated CYFRA 21-1 levels.
