Likewise, our comparison of the level of methylation of individual genes in different cancers (Additional file 3: Figure S3) supports the potential of multi-marker panels to provide increased sensitivity for detection in tissue samples, which is likely to be reflected in blood or stool-based assays.
Adopting a similar approach for RMLA might provide increased performance for dense marker maps.
Marker-assisted selection is more efficient when molecular maps are well saturated, as high-density maps provide increased opportunities for detecting polymorphic markers in genomic regions of interest.
In addition, the imaging markers are often measured over time, and this longitudinal profile may provide increased power for differentiating genotype groups.
Continued refinements of algorithm design are being made to provide increased sensitivity for cancer detection while diminishing the false marker rate.
However, in the (sensitivity) analyses there was little difference in the observed associations whether the data were obtained retrospectively or prospectively, or by self-report and/or some biochemical marker [ 19, 20], which provides increased confidence in the results.
Weight adjusted for height, as in the BMI metric, is likely to be a more sensitive marker of excess body fat providing increased statistical power to detect any association with TGCT.
All of these sites represent possible markers for ST-11, which by definition could differentiate ST-11 from other STs, thus providing increased resolution for subtyping.
Tools such as marker-assisted selection, inducible promoters, controllable male sterility, inducible apomixis and visual markers provide greater flexibility in local breeding and increase the range of varietal options from which farmers can choose.
When used together, these novel markers provide superior risk stratification.
