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Until recently, experimental evolution has been limited to measuring phenotypic changes, or to tracking a few genetic markers over time.
By measuring improvements in these surrogate markers over time, governments can track progress towards their overall goal of reducing maternal mortality.
Validation of the markers over time scales of milliseconds was achieved by showing that common types of sleep-EEG phasic events could be detected by recurrence analysis.
We did not observe any significant changes in discriminatory capacity of the markers over time.
One prerequisite for routine use is the stability of markers over time.
Moreover, estimates of change in these markers over time were very close to zero.
Similar(12)
While all individual repeated measurements of the kidney function over time were used on 48 occasions, a summary statistic such as the individual slope of the marker over time was used as the outcome variable on 45 occasions (Table 3).
When used to model individual repeated values of a quantitative marker of the renal function, both linear mixed models and linear GEE can be used to investigate risk factors associated with the mean trajectory of the marker over time.
It is unclear if biomarkers assessed in a stable state or in a more actively psychotic state will be more informative for clinical application and it may be that the degree of change for a given marker over time within the same person will be the most predictive.
(4) To extract additional information, criteria for a positive test should be based on combinations of individual markers and changes in marker levels over time.
That delay will be costly, the authors of the review say, as certain health markers fade over time and more persistent effects "are likely to be confounded by other types of exposures".
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CEO of Professional Science Editing for Scientists @ prosciediting.com