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Accurate assignment of exposure depends on the availability of effective markers of variation in exposure, whatever the underlying diversity of exposures may actually be.
According to Salazar et al. [ 23], common DNA polymorphisms in genes associated with lipid metabolism are potentially important genetic markers of variation in the plasma lipid profile and thus susceptibility or resistance to CAD.
Therefore, we selected SNPs that are markers of variation in larger segments of each of the five iron homeostasis genes (tagSNPs) based on linkage calculated using Haploview version 4.1 Barrettt 2009) for Asian population groups from Beijing and Tokyo [Han Chinese in Beijing, China (CHB) and Japanese in Tokyo, Japan (JPT)] included in Hapmap (http://hapmap.ncbi.nlm.nih.gov/citinghapmap.html.en).en
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Moreover, we suggested that metastatic synchronization can be quantified by the standard deviation of size and number of metastases at time of first recurrence, as a marker of variation in the metastatic pattern.
Isolates from single patients were variable for many traits commonly taken as a marker of variation in RpoS levels (breadth of carbon source utilization, motility, H2O2 and acid sensitivity, glycogen production, and the red dry and rough morphotype).
With the current state of knowledge, the opening and/or closure of the BHC in most species seems to be a marker of variations in the dosage of Shh and Shh pathway-related genes during cranial base and midline morphogenesis.
They also examined the genetic diversity of bee populations by analyzing microsatellites (short, repetitive DNA sequences that are useful markers of genetic variation in populations).
In summary, the InDels with a high amount of polymorphisms and a large size difference will be useful as density markers of genome variation for marker-assisted mapping of important rice traits as well as for rice breeding, and the data generated in this study will be a valuable resource for rice improvement.
Single nucleotide polymorphisms or (SNPs) are loci in the DNA sequence which can serve as markers of phenotypic variation.
The use of single-nucleotide polymorphisms (SNPs) as markers of genetic variation for phylogenetic analysis has been described in many studies [ 23– 28].
The SNPs will be useful as dense markers of genome variation for marker-assisted mapping of important soybean traits as well as for pinpointing agronomically important genes in soybeans.
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